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Trump's comments about "not voting" is a sign of desperation..


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4 hours ago, calguy said:

So simple to get a vaccination, yet the brainwashed among us are intent on doing everything the hard way. All because they believe the misinformation being pushed by the right.

By Trump!!!

People so stupid they will die on that hill with him!

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4 hours ago, freeman said:

Thank you so much for punctuating my point!
The 22 mechanisms of action of ivermectin against SARS-CoV2 virus.
 

Published in science Journal List - Nature Public Health Emergency Collection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203399/


"Fig. 1
A schematic of the key cellular and biomolecular interactions between Ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications.

Ivermectin; IVM (red block) inhibits and disrupts binding of the SARS-CoV-2 S protein at the ACE-2 receptors (green). The green dotted lines depict activation pathways and the red dotted lines depict the inhibition pathways. The TLR-4 receptors are directly activated by SARS-CoV-2 and also by LPS mediated activation (seen during ICU settings) causing activation of NF-Kb pathway and MAP3 Kinases leading to increased intranuclear gene expression for proinflammatory cytokines and chemokines (responsible for cytokine storm) and NO release (responsible for blood vessel dilatation, fluid leak, low blood pressure, ARDS and sepsis). The NF-Kb and STAT-3 pathway activation is central to the pathogenesis and sequelae of COVID-19. STAT-3 physically binds to PAK-1 and increases IL-6 transcription. The annexin A2 at the cell surface converts plasminogen; PLG to plasmin under the presence of t-PA. Plasmin triggers activation and nuclear translocation of STAT-3. An upregulation of STAT-3 stimulates hyaluronan synthase-2 in the lung cells causing hyaluronan deposition leading to diffuse alveolar damage and hypoxia. STAT-3 also directly activates TGF-beta initiating pulmonary fibrosis; a typical characteristic of SARS-COV-2 lung pathology. The damaged type 2 cells express PAI-1 and an already hypoxic state also causes an upregulation of PAI (through Hypoxic inducible factor-1) along with direct stimulation by STAT-3. Simultaneous STAT-3 and PAI-1 activation inhibits t-PA and urokinase-type plasminogen activator leading to thrombi formation. Also, the SARS-CoV-2 spike protein binds to the CD147 on red blood cells and causes clumping. IVM in turn, binds to SARS-CoV-2 Spike protein and hence prevents clumping. T cell lymphopenia in COVID-19 can also be attributed to the direct activation of PD-L1 receptors on endothelial cells by STAT-3. IVM directly inhibits the NF-kb pathway, STAT-3, and indirectly inhibits PAK-1 by increasing its ubiquitin-mediated degradation. The natural antiviral response of a cell is through interferon regulatory genes and viral RNA mediated activation of TLR-3 and TLR7/8- Myd88 activation of transcription of interferon-regulator (IRF) family. For a virus to establish an infection, this antiviral response needs to be inhibited by blocking interferon production. The proteins such as importin and KPNA mediate nuclear transport of viral protein and subsequent IFN signaling. The SARS-CoV-2 proteins (ORF-3a, NSP-1, and ORF-6) directly block IFN signaling causing the surrounding cells to become unsuspecting victims of the infection. IVM inhibits both importin a-b (green) as well as the KPNA-1 receptors (brown) causing natural antiviral IFN release. IVM also inhibits viral RdrP, responsible for viral replication. IVM Ivermectin, ACE-2 angiotensin-converting-enzyme 2, LPS Lipopolysaccharide, TLR Toll-like receptor, t-PA tissue-like plasminogen activator, PLG Plasminogen, IMPab Importin alpha-beta, Rdrp RNA dependant RNA polymerase, KPNA-1 Karyopherin Subunit Alpha 1, NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells, Map3Kinases Mitogen-activated Kinases, PAK-1 P21 Activated Kinase 1, STAT-3 Signal transducer and activator of transcription 3, PAI-1 Plasminogen activator inhibitor-1, HIF-1 Hypoxia-Inducible Factor"

41429_2021_430_Fig1_HTML.jpg

Trials and studies:

https://c19ivermectin.com/

 

metaci.png

 

So who's the horse's ass?

The guy that cites a cartoonist or the guy that cites the science?

You need to get help.

Dude, you don't cite science. You cite pseudoscience opinions from crack pot websites. 

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5 hours ago, calguy said:

Trump's comments about "not voting" is a sign of desperation..

In effect, he is telling Republican leaders to either stick with him during these tough times or he will tell his supporters to not vote in the next election. It is sort of similar to extortion.

He is desperate because the chickens are finally coming home to roost. His allies are due to report for a subpoena today and tomorrow. Even though he has advised them to declare "executive privilege, there really is not much he can do to save them. He cannot stop the documents from being turned over to the Select Committee. He cannot lie or deceive his way out this time.

It is just a matter of time before everyone sees that the king has no clothes. He will stand naked before the world.

Today is just the beginning.

you making two posts about the same thing you that you clearly misunderstood is a sign of desperation 

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1 hour ago, calguy said:

Dude, you don't cite science. You cite pseudoscience opinions from crack pot websites. 

Didn't you even look at the link?

If the NIH is "pseudoscience opinions from crack pot websites", which I firmly believe it generally is but am surprised that you agree considering your demigod and little naked emperor Doctor Death Fauci is all up in it, then what non-"crack pot websites" do you get your science from?

All I've noticed so far is that the "science" you keep posting comes from a cartoonist.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203399/

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23 minutes ago, freeman said:

Didn't you even look at the link?

If the NIH is "pseudoscience opinions from crack pot websites", which I firmly believe it generally is but am surprised that you agree considering your demigod and little naked emperor Doctor Death Fauci is all up in it, then what non-"crack pot websites" do you get your science from?

All I've noticed so far is that the "science" you keep posting comes from a cartoonist.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203399/

The following side effects and drug interactions that can occur with ivermectin are signs of ivermectin toxicity, according to the CDC:

  • Abdominal pain, nausea, vomiting, and diarrhea
  • Dizziness
  • Low blood pressure
  • Tachycardia (an abnormally fast heart rate)
  • Headache
  • Blurred vision and visual hallucinations
  • Confusion
  • Tremors and loss of coordination and balance
  • Seizures
  • Central nervous system depression, decreased alertness, and coma

Ivermectin can also be dangerous when mixed with drugs that also can suppress the central nervous system, like benzodiazepines and barbiturates. It can sometimes increase the risk of side effects in people taking the blood-thinning drug warfarin

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14 minutes ago, calguy said:

The following side effects and drug interactions that can occur with ivermectin are signs of ivermectin toxicity, according to the CDC:

  • Abdominal pain, nausea, vomiting, and diarrhea
  • Dizziness
  • Low blood pressure
  • Tachycardia (an abnormally fast heart rate)
  • Headache
  • Blurred vision and visual hallucinations
  • Confusion
  • Tremors and loss of coordination and balance
  • Seizures
  • Central nervous system depression, decreased alertness, and coma

Ivermectin can also be dangerous when mixed with drugs that also can suppress the central nervous system, like benzodiazepines and barbiturates. It can sometimes increase the risk of side effects in people taking the blood-thinning drug warfarin

Look at you talking about what ifs...

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39 minutes ago, freeman said:

Didn't you even look at the link?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203399/

I looked at the link. Found out it was, like almost everything you post, bogus information. It was so bogus, in fact, that the article was retracted. 


RETRACTED ARTICLE: The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article

The Journal of Antibiotics (2021)Cite this article

  • The Editor-in-Chief has retracted this article. Following publication, concerns were raised regarding the methodology and the conclusions of this review article. Postpublication review confirmed that while the review article appropriately describes the mechanism of action of ivermectin, the cited sources do not appear to show that there is clear clinical evidence of the effect of ivermectin for the treatment of SARS-CoV-2. The Editor-in-Chief therefore no longer has confidence in the reliability of this review article. None of the authors agree to this retraction. The online version of this article contains the full text of the retracted article as Supplementary Information.

  • https://www.nature.com/articles/s41429-021-00430-5

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9 hours ago, calguy said:

Trump's comments about "not voting" is a sign of desperation..

In effect, he is telling Republican leaders to either stick with him during these tough times or he will tell his supporters to not vote in the next election. It is sort of similar to extortion.
 

The desperation is liberal idiots deliberately lying about what Trump said. 

Trump said Republicans wouldn't vote if they couldn't trust elections.  That's a fact. 

He never told Republicans not to vote. 

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9 hours ago, calguy said:

Trump's comments about "not voting" is a sign of desperation..

In effect, he is telling Republican leaders to either stick with him during these tough times or he will tell his supporters to not vote in the next election. It is sort of similar to extortion.

He is desperate because the chickens are finally coming home to roost. His allies are due to report for a subpoena today and tomorrow. Even though he has advised them to declare "executive privilege, there really is not much he can do to save them. He cannot stop the documents from being turned over to the Select Committee. He cannot lie or deceive his way out this time.

It is just a matter of time before everyone sees that the king has no clothes. He will stand naked before the world.

Today is just the beginning.

BRING IT ON!

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